| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TDRD9 (300-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TDRD9 |
| Gene ID: |
122402 |
| Uniprot ID: |
TDRD9_HUMAN |
| Immunogen Region: |
300-600 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human TDRD9 (NP_694591.2). |
| Immunogen Sequence: |
AVPVQNKMNPAYIFEVEGKP HSVEEYYLNDLEHIHHSKLS PHLLEEPVITKDIYEVAVSL IQMFDDLDMKESGNKAWSGA QFVLERSSVLVFLPGLGEIN YMHELLTSLVHKRLQVYPLH SSVALEEQNNVFLSPVPGYR KIILSTNIAESSVTVPDVKY VIDFCLTRTLVCDEDTNYQS LRLSWASKTSCNQRKGRAGR VSRGYCYRLVHKDFWDNSIP DHVVPEMLRCPLGSTILKV |
| Function | ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. |
| Protein Name | Atp-Dependent Rna Helicase Tdrd9Tudor Domain-Containing Protein 9 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmNucleusComponent Of The NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisSpecifically Localizes To Pip-BodiesA Subset Of The Nuage Which Contains Secondary PirnasPiwil2 Is Required For Its Localization To Pip-Bodies |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Tdrd9 antibodyAnti-Tudor Domain-Containing Protein 9 antibodyAnti-TDRD9 antibodyAnti-C14orf75 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
