| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TCIRG1 (1-130) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TCIRG1 |
| Gene ID: |
10312 |
| Uniprot ID: |
VPP3_HUMAN |
| Immunogen Region: |
1-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human TCIRG1 (NP_006010.2). |
| Immunogen Sequence: |
MGSMFRSEEVALVQLFLPTA AAYTCVSRLGELGLVEFRDL NASVSAFQRRFVVDVRRCEE LEKTFTFLQEEVRRAGLVLP PPKGRLPAPPPRDLLRIQEE TERLAQELRDVRGNQQALRA QLHQLQLHAA |
| Tissue Specificity | Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus. |
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Seems to be directly involved in T-cell activation. |
| Protein Name | V-Type Proton Atpase 116 Kda Subunit A 3V-Atpase 116 Kda Subunit A 3Osteoclastic Proton Pump 116 Kda SubunitOc-116 KdaOc116T-Cell Immune Regulator 1T-Cell Immune Response Cdna7 ProteinTirc7Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 3 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-6798695Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-V-Type Proton Atpase 116 Kda Subunit A 3 antibodyAnti-V-Atpase 116 Kda Subunit A 3 antibodyAnti-Osteoclastic Proton Pump 116 Kda Subunit antibodyAnti-Oc-116 Kda antibodyAnti-Oc116 antibodyAnti-T-Cell Immune Regulator 1 antibodyAnti-T-Cell Immune Response Cdna7 Protein antibodyAnti-Tirc7 antibodyAnti-Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 3 antibodyAnti-TCIRG1 antibodyAnti-ATP6N1C antibodyAnti-ATP6V0A3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
