| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELOA |
| Gene ID: | 6924 |
| Uniprot ID: | ELOA1_HUMAN |
| Immunogen Region: | 679-798 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 679-798 of human TCEB3 (NP_003189.2). |
| Immunogen Sequence: | ANKPKGRQAKMAFVNSVAKP PRDVRRRQEKFGTGGAAVPE KIKIKPAPYPMGSSHASASS ISFNPSPEEPAYDGPSTSSA HLAPVVSSTVSYDPRKPTVK KIAPMMAKTIKAFKNRFSRR |
| Function | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5.polyubiquitinates monoubiquitinated POLR2A. |
| Protein Name | Elongin-A Eloa Elongin 110 Kda Subunit Rna Polymerase Ii Transcription Factor Siii Subunit A1 Siii P110 Transcription Elongation Factor B Polypeptide 3 |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-167152 Reactome: R-HSA-167200 Reactome: R-HSA-167238 Reactome: R-HSA-167243 Reactome: R-HSA-167246 Reactome: R-HSA-167287 Reactome: R-HSA-167290 Reactome: R-HSA-674695 Reactome: R-HSA-6796648 Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus Localizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Elongin-A antibody Anti-Eloa antibody Anti-Elongin 110 Kda Subunit antibody Anti-Rna Polymerase Ii Transcription Factor Siii Subunit A1 antibody Anti-Siii P110 antibody Anti-Transcription Elongation Factor B Polypeptide 3 antibody Anti-ELOA antibody Anti-TCEB3 antibody Anti-MSTP059 antibody |
Information sourced from Uniprot.org