| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBP |
| Gene ID: | 6908 |
| Uniprot ID: | TBP_HUMAN |
| Immunogen Region: | 160-319 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-319 of human TBP (NP_001165556.1). |
| Immunogen Sequence: | LKTIALRARNAEYNPKRFAA VIMRIREPRTTALIFSSGKM VCTGAKSEEQSRLAARKYAR VVQKLGFPAKFLDFKIQNMV GSCDVKFPIRLEGLVLTHQQ FSSYEPELFPGLIYRMIKPR IVLLIFVSGKVVLTGAKVRA EIYEAFENIYPILKGFRKTT |
| Tissue Specificity | Widely expressed, with levels highest in the testis and ovary. |
| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TBP forms the TFIID-A module together with TAF3 and TAF5. TBP is a general transcription factor that functions at the core of the TFIID complex. During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. |
| Protein Name | Tata-Box-Binding Protein Tata Sequence-Binding Protein Tata-Binding Factor Tata-Box Factor Transcription Initiation Factor Tfiid Tbp Subunit |
| Database Links | Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-427359 Reactome: R-HSA-427413 Reactome: R-HSA-5250924 Reactome: R-HSA-674695 Reactome: R-HSA-6804756 Reactome: R-HSA-6807505 Reactome: R-HSA-73762 Reactome: R-HSA-73772 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-73863 Reactome: R-HSA-749476 Reactome: R-HSA-75953 Reactome: R-HSA-76042 Reactome: R-HSA-76061 Reactome: R-HSA-76066 Reactome: R-HSA-76071 Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Tata-Box-Binding Protein antibody Anti-Tata Sequence-Binding Protein antibody Anti-Tata-Binding Factor antibody Anti-Tata-Box Factor antibody Anti-Transcription Initiation Factor Tfiid Tbp Subunit antibody Anti-TBP antibody Anti-GTF2D1 antibody Anti-TF2D antibody Anti-TFIID antibody |
Information sourced from Uniprot.org