| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TBCD |
| Gene ID: |
6904 |
| Uniprot ID: |
TBCD_HUMAN |
| Immunogen Region: |
1-240 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human TBCD (NP_005984.3). |
| Immunogen Sequence: |
MALSDEPAAGGPEEEAEDET LAFGAALEAFGESAETRALL GRLREVHGGGAEREVALERF RVIMDKYQEQPHLLDPHLEW MMNLLLDIVQDQTSPASLVH LAFKFLYIITKVRGYKTFLR LFPHEVADVEPVLDLVTIQN PKDHEAWETRYMLLLWLSVT CLIPFDFSRLDGNLLTQPGQ ARMSIMDRILQIAESYLIVS DKARDAAAVLVSRFITRPDV KQSKMAEFLDWSLCNLARS |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis. |
| Protein Name | Tubulin-Specific Chaperone DBeta-Tubulin Cofactor DTfcdSsd-1Tubulin-Folding Cofactor D |
| Database Links | Reactome: R-HSA-389977 |
| Cellular Localisation | Cell JunctionTight JunctionLateral Cell MembraneCytoplasmAdherens JunctionCytoskeletonMicrotubule Organizing CenterCentrosomeLocalized In Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Tubulin-Specific Chaperone D antibodyAnti-Beta-Tubulin Cofactor D antibodyAnti-Tfcd antibodyAnti-Ssd-1 antibodyAnti-Tubulin-Folding Cofactor D antibodyAnti-TBCD antibodyAnti-KIAA0988 antibodyAnti-SSD1 antibodyAnti-TFCD antibodyAnti-PP1096 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
