| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBC1 domain family member 23 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBC1D23 |
| Gene ID: |
55773 |
| Uniprot ID: |
TBC23_HUMAN |
| Specificity: |
This antibody detects endogenous levels of TBC1D23 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human TBC1D23 |
| Function | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. |
| Protein Name | Tbc1 Domain Family Member 23Hcv Non-Structural Protein 4a-Transactivated Protein 1 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkCytoplasmic VesicleLocalization To The Trans-Golgi Is Regulated By Arl1 And Arl5b/Arl8Arl1 Increases Golgi LocalizationWhile Arl5b Decreases ItRecruitment To The Trans-Golgi Network Requires The Presence Of Golga1 And Golga4But Not That Of Fam91a1Recruited On Ap-1-Derived Vesicles By Wdr11 Complex |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 23 antibodyAnti-Hcv Non-Structural Protein 4a-Transactivated Protein 1 antibodyAnti-TBC1D23 antibodyAnti-NS4ATP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
