| Tissue Specificity | Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |
| Post Translational Modifications | Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2. |
| Function | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). |
| Protein Name | Serine/Threonine-Protein Kinase Tao3Cutaneous T-Cell Lymphoma-Associated Antigen Hd-Cl-09Ctcl-Associated Antigen Hd-Cl-09Dendritic Cell-Derived Protein KinaseJnk/Sapk-Inhibitory KinaseJun Kinase-Inhibitory KinaseKinase From Chicken Homolog AHkfc-AThousand And One Amino Acid Protein 3 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinAlso Localized To The Peripheral Cell Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao3 antibodyAnti-Cutaneous T-Cell Lymphoma-Associated Antigen Hd-Cl-09 antibodyAnti-Ctcl-Associated Antigen Hd-Cl-09 antibodyAnti-Dendritic Cell-Derived Protein Kinase antibodyAnti-Jnk/Sapk-Inhibitory Kinase antibodyAnti-Jun Kinase-Inhibitory Kinase antibodyAnti-Kinase From Chicken Homolog A antibodyAnti-Hkfc-A antibodyAnti-Thousand And One Amino Acid Protein 3 antibodyAnti-TAOK3 antibodyAnti-DPK antibodyAnti-JIK antibodyAnti-KDS antibodyAnti-MAP3K18 antibody |
Information sourced from Uniprot.org
