| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Trace amine-associated receptor 1 (110-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAAR1 |
| Gene ID: | 134864 |
| Uniprot ID: | TAAR1_HUMAN |
| Immunogen Region: | 110-190 aa |
| Specificity: | TAAR1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 110-190 |
| Function | Intracellular G-protein coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine. Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand. CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity. T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers. TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes. Amphetamine-binding is coupled with G(s)- or G(12)/G(13) G alpha protein subtypes. |
| Protein Name | Trace Amine-Associated Receptor 1 Tar-1 Trace Amine Receptor 1 |
| Database Links | Reactome: R-HSA-375280 Reactome: R-HSA-418555 |
| Cellular Localisation | Endomembrane System Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cell Membrane Localizes Mainly Intracellularly Partially Colocalizes With The Endoplasmic Reticulum Also Found At Lower Lever At The Plasma Membrane |
| Alternative Antibody Names | Anti-Trace Amine-Associated Receptor 1 antibody Anti-Tar-1 antibody Anti-Trace Amine Receptor 1 antibody Anti-TAAR1 antibody Anti-TA1 antibody Anti-TAR1 antibody Anti-TRAR1 antibody |
Information sourced from Uniprot.org