| Post Translational Modifications | N-glycosylated. Upon expression in a kidney cell line the most abundant glycan on Asn-534 is GlcNAc(3)Hex(5), while on Asn-559 and Asn-565 the most abundant glycan is GlcNAc2Fuc1Man3GlcNAc3Gal3. Both Asn-559 and Asn-565 have a high degree of glycan heterogeneity. |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA).the toxin probably binds via extracellular loop 4. Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation.glycosylation of Asn-559 increases its affinity for BoNT/A. Also serves as a receptor for the closely related C.botulinum neurotoxin type A2.glycosylation is not essential but enhances the interaction. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD).note that type D does not usually infect humans. |
| Protein Name | Synaptic Vesicle Glycoprotein 2c |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinEnriched In Small Synaptic Vesicles And Adrenal MicrosomesNot Present In Chromaffin GranulesAssociated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The Pancreas |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2c antibodyAnti-SV2C antibodyAnti-KIAA1054 antibody |
Information sourced from Uniprot.org
