Anti-SV-40 antibody [MRQ-4] (STJ16100426)

Anti-SV-40 antibody [MRQ-4] (STJ16100426)

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STJ16100426
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-SV-40 is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : MRQ-4
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Dilution Range: IHC 1:50 – 1:200
Storage Instruction: Store at 2-8°C upon receipt.
Background SV40, Simian Virus 40 is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the transcriptional properties of tumor-suppressing p53 in humans through the SV40 large T-antigen and SV40 small T-antigen. It is generally assumed that large T-antigen is the major protein involved in neoplastic processes and the large T-antigen predominantly exerts its effect through deregulation of tumor suppressor p53, which is responsible for initiating regulated cell death (“apoptosis”) , or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor.

Information sourced from Uniprot.org

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