Tissue Specificity | Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart. |
Post Translational Modifications | N-glycosylated. Contains high-mannose-type oligosaccharides. |
Function | Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. |
Protein Name | Formylglycine-Generating EnzymeFgeC-Alpha-Formylglycine-Generating Enzyme 1Sulfatase-Modifying Factor 1 |
Database Links | Reactome: R-HSA-1663150Reactome: R-HSA-9840310 |
Cellular Localisation | Endoplasmic Reticulum Lumen |
Alternative Antibody Names | Anti-Formylglycine-Generating Enzyme antibodyAnti-Fge antibodyAnti-C-Alpha-Formylglycine-Generating Enzyme 1 antibodyAnti-Sulfatase-Modifying Factor 1 antibodyAnti-SUMF1 antibodyAnti-PSEC0152 antibodyAnti-UNQ3037 antibodyAnti-PRO9852 antibody |
Information sourced from Uniprot.org