| Tissue Specificity | Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages. |
| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. |
| Protein Name | Metalloreductase Steap4Six-Transmembrane Epithelial Antigen Of Prostate 4Sixtransmembrane Protein Of Prostate 2Tumor Necrosis Factor - Alpha-Induced Protein 9 |
| Database Links | Reactome: R-HSA-917977 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Metalloreductase Steap4 antibodyAnti-Six-Transmembrane Epithelial Antigen Of Prostate 4 antibodyAnti-Sixtransmembrane Protein Of Prostate 2 antibodyAnti-Tumor Necrosis Factor - Alpha-Induced Protein 9 antibodyAnti-STEAP4 antibodyAnti-STAMP2 antibodyAnti-TNFAIP9 antibody |
Information sourced from Uniprot.org
