| Tissue Specificity | Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. |
| Post Translational Modifications | Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner. Glycosylated. |
| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Mediates efficient transferrin-dependent iron uptake in erythroid cells. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. |
| Protein Name | Metalloreductase Steap3Dudulin-2Six-Transmembrane Epithelial Antigen Of Prostate 3Tumor Suppressor-Activated Pathway Protein 6Htsap6PhydeHphyde |
| Database Links | Reactome: R-HSA-6803204Reactome: R-HSA-9013148Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9035034Reactome: R-HSA-917977 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinLocalizes To Vesicular-Like Structures At The Plasma Membrane And Around The Nucleus |
| Alternative Antibody Names | Anti-Metalloreductase Steap3 antibodyAnti-Dudulin-2 antibodyAnti-Six-Transmembrane Epithelial Antigen Of Prostate 3 antibodyAnti-Tumor Suppressor-Activated Pathway Protein 6 antibodyAnti-Htsap6 antibodyAnti-Phyde antibodyAnti-Hphyde antibodyAnti-STEAP3 antibodyAnti-TSAP6 antibody |
Information sourced from Uniprot.org
