| Post Translational Modifications | Glycosylated.autosialylated. |
| Function | Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis. Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins. Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers. Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation. |
| Protein Name | Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 1Galnac Alpha-2 -6-Sialyltransferase ISt6galnac ISt6galnac-ISt6galnaciHst6galnac-ISialyltransferase 7aSiat7-A |
| Database Links | Reactome: R-HSA-4085001 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 1 antibodyAnti-Galnac Alpha-2 -6-Sialyltransferase I antibodyAnti-St6galnac I antibodyAnti-St6galnac-I antibodyAnti-St6galnaci antibodyAnti-Hst6galnac-I antibodyAnti-Sialyltransferase 7a antibodyAnti-Siat7-A antibodyAnti-ST6GALNAC1 antibodyAnti-SIAT7A antibodyAnti-UNQ543 antibodyAnti-PRO848 antibody |
Information sourced from Uniprot.org
