| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SRGAP2 (790-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRGAP2 |
| Gene ID: |
23380 |
| Uniprot ID: |
SRGP2_HUMAN |
| Immunogen Region: |
790-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 790-900 of human SRGAP2 (NP_056141.2). |
| Immunogen Sequence: |
GVVERSSPKSEIEVISEPPE EKVTARAGASCPSGGHVADI YLANINKQRKRPESGSIRKT FRSDSHGLSSSLTDSSSPGV GASCRPSSQPIMSQSLPKEG PDKCSISGHGS |
| Post Translational Modifications | Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions. |
| Function | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. |
| Protein Name | Slit-Robo Rho Gtpase-Activating Protein 2Srgap2Formin-Binding Protein 2Rho Gtpase-Activating Protein 34 |
| Database Links | Reactome: R-HSA-428543Reactome: R-HSA-5663220Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013406Reactome: R-HSA-9013420Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | Cell MembraneCell ProjectionDendritic SpinePostsynaptic DensityPostsynaptic Cell MembraneLamellipodiumCytoplasmic VesiclePhagosomeNucleusCytoplasmCytosolRecruited To Actin-Rich Phagosomes During PhagocytosisTranslocates From Nucleus To Cytoplasm During Development |
| Alternative Antibody Names | Anti-Slit-Robo Rho Gtpase-Activating Protein 2 antibodyAnti-Srgap2 antibodyAnti-Formin-Binding Protein 2 antibodyAnti-Rho Gtpase-Activating Protein 34 antibodyAnti-SRGAP2 antibodyAnti-ARHGAP34 antibodyAnti-FNBP2 antibodyAnti-KIAA0456 antibodyAnti-SRGAP2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
