| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRGAP1 |
| Gene ID: | 57522 |
| Uniprot ID: | SRGP1_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRGAP1 (NP_065813.1). |
| Immunogen Sequence: | MSTPSRFKKDKEIIAEYESQ VKEIRAQLVEQQKCLEQQTE MRVQLLQDLQDFFRKKAEIE TEYSRNLEKLAERFMAKTRS TKDHQQYKKDQNLLSPVNCW YLLLNQVRRESKDHATLSDI YLNNVIMRFMQISEDSTRMF KKSKEIAFQLHEDLMKVLNE |
| Tissue Specificity | Expressed in brain, lung, kidney, and testis. |
| Function | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. |
| Protein Name | Slit-Robo Rho Gtpase-Activating Protein 1Srgap1Rho Gtpase-Activating Protein 13 |
| Database Links | Reactome: R-HSA-428543Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Alternative Antibody Names | Anti-Slit-Robo Rho Gtpase-Activating Protein 1 antibodyAnti-Srgap1 antibodyAnti-Rho Gtpase-Activating Protein 13 antibodyAnti-SRGAP1 antibodyAnti-ARHGAP13 antibodyAnti-KIAA1304 antibody |
Information sourced from Uniprot.org