| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination. Ubiquitinated.leading to degradation by the proteasome. |
| Function | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. |
| Protein Name | Sprouty-Related - Evh1 Domain-Containing Protein 2Spred-2 |
| Database Links | Reactome: R-HSA-5658442Reactome: R-HSA-5658623Reactome: R-HSA-6802953 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleSecretory Vesicle MembraneCytoplasmDetected In The Cytoplasm Of The Stratum Spinosum CellsWhere It Is Associated With Cytoplasmic Vesicles That Are Supposed To Be Secretory Granules |
| Alternative Antibody Names | Anti-Sprouty-Related - Evh1 Domain-Containing Protein 2 antibodyAnti-Spred-2 antibodyAnti-SPRED2 antibody |
Information sourced from Uniprot.org
