| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. |
| Protein Name | Sperm-Associated Antigen 8Hsd-1Sperm Membrane Protein 1Smp-1Sperm Membrane Protein Bs-84 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleSecretory VesicleAcrosomeCytoskeletonMicrotubule Organizing CenterSpindleCilium AxonemeFlagellum AxonemeIn Mature Sperm CellsDetected In The Acrosomal Region Of The Head And In The Middle Piece Of The TailLocalized To The Nucleus And Cytoplasm Of Spermatocytes And Round Spermatids WhileIn Elongating SpermatidsExpressed In The Cytoplasm But Not In The NucleusDuring The Cell CycleLocalized On The Microtubule-Organizing Center (Mtoc) During ProphaseIn MetaphaseExtends Along Spindle MicrotubulesIn AnaphaseDetected On The Astral Microtubules And Mid-ZoneIn TelophaseRemains At The Mid-ZoneAfter CytokinesisReturns To The MtocMicrotubule Inner Protein (Mip) Part Of The Dynein-Decorated Doublet Microtubules (Dmts) In Cilia Axoneme |
| Alternative Antibody Names | Anti-Sperm-Associated Antigen 8 antibodyAnti-Hsd-1 antibodyAnti-Sperm Membrane Protein 1 antibodyAnti-Smp-1 antibodyAnti-Sperm Membrane Protein Bs-84 antibodyAnti-SPAG8 antibody |
Information sourced from Uniprot.org
