| Function | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression. Positively regulates the transcription of the core clock component ARNTL/BMAL1. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112. |
| Protein Name | Transcription Factor Sp1Specificity Protein 1 |
| Database Links | Reactome: R-MMU-2173796Reactome: -MMU-6807505Reactome: -MMU-9018519 |
| Cellular Localisation | NucleusCytoplasmNuclear Location Is Governed By Glycosylated/Phosphorylated StatesInsulin Promotes Nuclear LocationWhile Glucagon Favors Cytoplasmic Location |
| Alternative Antibody Names | Anti-Transcription Factor Sp1 antibodyAnti-Specificity Protein 1 antibodyAnti-Sp1 antibody |
Information sourced from Uniprot.org
