| Host: |
Mouse |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Suppressor of cytokine signaling 1 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
5C3 |
| Conjugation: |
Unconjugated |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOCS1 |
| Gene ID: |
8651 |
| Uniprot ID: |
SOCS1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SOCS-1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from the human SOCS-1 |
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 1Socs-1Jak-Binding ProteinJabStat-Induced Stat Inhibitor 1Ssi-1Tec-Interacting Protein 3Tip-3 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-1433559Reactome: R-HSA-166058Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9705462Reactome: R-HSA-982772Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmic VesicleDetected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 1 antibodyAnti-Socs-1 antibodyAnti-Jak-Binding Protein antibodyAnti-Jab antibodyAnti-Stat-Induced Stat Inhibitor 1 antibodyAnti-Ssi-1 antibodyAnti-Tec-Interacting Protein 3 antibodyAnti-Tip-3 antibodyAnti-SOCS1 antibodyAnti-SSI1 antibodyAnti-TIP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
