| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SNX5 (145-404) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNX5 |
| Gene ID: |
27131 |
| Uniprot ID: |
SNX5_HUMAN |
| Immunogen Region: |
145-404 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 145-404 of human SNX5 (NP_055241.1). |
| Immunogen Sequence: |
VFLQRLSSHPVLSKDRNFHV FLEYDQDLSVRRKNTKEMFG GFFKSVVKSADEVLFTGVKE VDDFFEQEKNFLINYYNRIK DSCVKADKMTRSHKNVADDY IHTAACLHSLALEEPTVIKK YLLKVAELFEKLRKVEGRVS SDEDLKLTELLRYYMLNIEA AKDLLYRRTKALIDYENSNK ALDKARLKSKDVKLAEAHQQ ECCQKFEQLSESAKEELINF KRKRVAAFRKNLIEMSELE |
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation.the function involves PIP5K1C isoform 3 and is retromer-independent. Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation.inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. Plays a role in macropinocytosis. |
| Protein Name | Sorting Nexin-5 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | EndosomeEarly EndosomeEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCytoplasmic Vesicle MembraneCytoplasmCell ProjectionPhagocytic CupRuffleRecruited To The Plasma Membrane After Egf StimulationWhich Leads To Increased Levels Of Phosphatidylinositol 34-Bisphosphate (Pdtins(34)P2)Detected On MacropinosomesTargeted To Membrane Ruffles In Response To Egfr Stimulation |
| Alternative Antibody Names | Anti-Sorting Nexin-5 antibodyAnti-SNX5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
