| Function | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis. Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+). |
| Protein Name | Sodium/Calcium Exchanger 3Na(+/Ca(2+-Exchange Protein 3Solute Carrier Family 8 Member 3 |
| Database Links | Reactome: R-MMU-418359Reactome: -MMU-425561Reactome: -MMU-5578775 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPerikaryonCell ProjectionDendriteDendritic SpineSarcolemmaCytoplasmSarcoplasmCell JunctionMitochondrion Outer MembranePerinuclear RegionEndoplasmic Reticulum MembraneDetected At Neuromuscular JunctionsIsoform 1: Cell MembraneIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Sodium/Calcium Exchanger 3 antibodyAnti-Na(+/Ca(2+-Exchange Protein 3 antibodyAnti-Solute Carrier Family 8 Member 3 antibodyAnti-Slc8a3 antibodyAnti-Ncx3 antibody |
Information sourced from Uniprot.org
