| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC4A10 (640-725) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC4A10 |
| Gene ID: |
57282 |
| Uniprot ID: |
S4A10_HUMAN |
| Immunogen Region: |
640-725 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 640-725 of human SLC4A10 (NP_001171486.1). |
| Immunogen Sequence: |
ALEKLFELSEAYPINMHNDL ELLTQYSCNCVEPHNPSNGT LKEWRESNISASDIIWENLT VSECKSLHGEYVGRACGHDH PYVPDV |
| Tissue Specificity | Predominantly expressed in the brain. |
| Function | Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange. Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid. Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity. Required in retinal cells to maintain normal pH which is necessary for normal vision. In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules. |
| Protein Name | Sodium-Driven Chloride Bicarbonate ExchangerSolute Carrier Family 4 Member 10 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCell ProjectionDendriteAxonPerikaryonPresynapsePostsynapseDetected In Dendrites And Axon Terminals Of Retinal Off Bipolar Cells And In Axon Terminals Of On Bipolar CellsIn Amacrine CellsLocated In The PerikaryonAlso Detected In Basal And Apical Dendrites Of Hippocampal Pyramidal Cells |
| Alternative Antibody Names | Anti-Sodium-Driven Chloride Bicarbonate Exchanger antibodyAnti-Solute Carrier Family 4 Member 10 antibodyAnti-SLC4A10 antibodyAnti-NBCN2 antibodyAnti-NCBE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
