| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC39A6 |
| Gene ID: | 25800 |
| Uniprot ID: | S39A6_HUMAN |
| Immunogen Region: | 170-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-320 of human SLC39A6 (NP_001092876.1). |
| Immunogen Sequence: | KQFKDKKKKNQKKPENDDDV EIKKQLSKYESQLSTNEEKV DTDDRTEGYLRADSQEPSHF DSQQPAVLEEEEVMIAHAHP QEVYNEYVPRGCKNKCHSHF HDTLGQSDDLIHHHHDYHHI LHHHHHQNHHPHSHSQRYSR EELKDAGVATL |
| Tissue Specificity | Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. |
| Post Translational Modifications | Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. |
| Function | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition. |
| Protein Name | Zinc Transporter Zip6 Estrogen-Regulated Protein Liv-1 Solute Carrier Family 39 Member 6 Zrt- And Irt-Like Protein 6 Zip-6 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Lamellipodium Membrane Membrane Raft Apical Cell Membrane Localizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr Stimulation In The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells |
| Alternative Antibody Names | Anti-Zinc Transporter Zip6 antibody Anti-Estrogen-Regulated Protein Liv-1 antibody Anti-Solute Carrier Family 39 Member 6 antibody Anti-Zrt- And Irt-Like Protein 6 antibody Anti-Zip-6 antibody Anti-SLC39A6 antibody Anti-LIV1 antibody Anti-ZIP6 antibody |
Information sourced from Uniprot.org