| Function | Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation. In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle. The transport activity is pH sensitive and Li(+) tolerant. Moreover functions in both direction and is associated with large uncoupled fluxes of protons. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+). May have a particular importance for modulation of net hepatic glutamine flux. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Transporter 5Solute Carrier Family 38 Member 5System N Transporter 2 |
| Database Links | Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At Astroglial Membrane |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Transporter 5 antibodyAnti-Solute Carrier Family 38 Member 5 antibodyAnti-System N Transporter 2 antibodyAnti-SLC38A5 antibodyAnti-JM24 antibodyAnti-SN2 antibodyAnti-SNAT5 antibodyAnti-PP7194 antibody |
Information sourced from Uniprot.org
