| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC38A3 |
| Gene ID: | 10991 |
| Uniprot ID: | S38A3_HUMAN |
| Immunogen Region: | 1-65 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human SLC38A3 (NP_006832.1). |
| Immunogen Sequence: | MEAPLQTEMVELVPNGKHSE GLLPVITPMAGNQRVEDPAR SCMEGKSFLQKSPSKEPHFT DFEGK |
| Function | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine. The transport activity is specific for L-glutamine, L-histidine and L-asparagine. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions. Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport. In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Transporter 3 N-System Amino Acid Transporter 1 Na(+-Coupled Neutral Amino Acid Transporter 3 Solute Carrier Family 38 Member 3 System N Amino Acid Transporter 1 |
| Database Links | Reactome: R-HSA-352230 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane The Localization Appears To Be Basolateral In The Plasma Membrane Of Hepatocytes Surrounding The Central Vein Localized At The Cerebrospinal Fluid (Csf)-Facing Membrane Of The Choroid Plexus Epithelial Cells In Astrocytes The Localization At Cell Membrane Is Decreased By Ammonia Through The Pkc Signaling Expressed In Both Luminal And Abluminal Plasma Membranes Of Larger Microvessels And Blood Brain Barrier (Bbb) Capillaries Restricted To The Basolateral Membranes Of S3 Segment Cells Of The Proximal Tubules |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Transporter 3 antibody Anti-N-System Amino Acid Transporter 1 antibody Anti-Na(+-Coupled Neutral Amino Acid Transporter 3 antibody Anti-Solute Carrier Family 38 Member 3 antibody Anti-System N Amino Acid Transporter 1 antibody Anti-SLC38A3 antibody Anti-G17 antibody Anti-NAT1 antibody Anti-SN1 antibody Anti-SNAT3 antibody |
Information sourced from Uniprot.org