| Tissue Specificity | Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis. Highly expressed in cytotrophoblast cells from term placenta. |
| Post Translational Modifications | N-glycosylation plays an important role in the L-glutamine transport. |
| Function | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis. May also contributes to amino acid transport in placental trophoblasts. Also regulates synaptic plasticity. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Symporter 1Amino Acid Transporter A1N-System Amino Acid Transporter 2Solute Carrier Family 38 Member 1System A Amino Acid Transporter 1System N Amino Acid Transporter 1 |
| Database Links | Reactome: R-HSA-210455Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRestricted To The Somatodendritic Compartment Of NeuronsFound In The Cellular Processes Of Neurons In The Developing Brain |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Symporter 1 antibodyAnti-Amino Acid Transporter A1 antibodyAnti-N-System Amino Acid Transporter 2 antibodyAnti-Solute Carrier Family 38 Member 1 antibodyAnti-System A Amino Acid Transporter 1 antibodyAnti-System N Amino Acid Transporter 1 antibodyAnti-SLC38A1 antibodyAnti-ATA1 antibodyAnti-NAT2 antibodyAnti-SAT1 antibodyAnti-SNAT1 antibody |
Information sourced from Uniprot.org
