| Tissue Specificity | Brain. Expressed at high levels within the neocortex, hippocampus, cerebellum, striatum, septal nuclei and the reticular nucleus of the thalamus. Also expressed in islets where it is more abundant in the peripheral/mantle region. Highly expressed in the nerve endings of GABA neurons in the brain and spinal cord but also in glycinergic nerve endings. Expressed in glycine-, GABA- or GABA- and glycine-containing boutons. |
| Function | Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake. |
| Protein Name | Vesicular Inhibitory Amino Acid TransporterGaba And Glycine TransporterSolute Carrier Family 32 Member 1Vesicular Gaba TransporterRgvatRat Unc-47 HomologRunc-47 |
| Database Links | Reactome: R-RNO-425393Reactome: -RNO-888590 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinPresynapsePresents In Glycine-Gaba- Or Gaba- And Glycine-Containing Boutons |
| Alternative Antibody Names | Anti-Vesicular Inhibitory Amino Acid Transporter antibodyAnti-Gaba And Glycine Transporter antibodyAnti-Solute Carrier Family 32 Member 1 antibodyAnti-Vesicular Gaba Transporter antibodyAnti-Rgvat antibodyAnti-Rat Unc-47 Homolog antibodyAnti-Runc-47 antibodyAnti-Slc32a1 antibodyAnti-Vgat antibodyAnti-Viaat antibody |
Information sourced from Uniprot.org
