| Tissue Specificity | Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung. In testis, primarily localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells, and weakly expressed in Leydig cells, peritubular myoid cells and germ cells. |
| Function | Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). |
| Protein Name | Sodium/Nucleoside Cotransporter 2Concentrative Nucleoside Transporter 2Cnt 2Hcnt2Na(+/Nucleoside Cotransporter 2Sodium-Coupled Nucleoside Transporter 2Sodium/Purine Nucleoside Co-TransporterSpntSolute Carrier Family 28 Member 2 |
| Database Links | Reactome: R-HSA-83936Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinApicolateral Cell MembraneLocalized To The Apicolateral Membranes Of Sertoli Cells And Vascular Endothelial Cells In Testis |
| Alternative Antibody Names | Anti-Sodium/Nucleoside Cotransporter 2 antibodyAnti-Concentrative Nucleoside Transporter 2 antibodyAnti-Cnt 2 antibodyAnti-Hcnt2 antibodyAnti-Na(+/Nucleoside Cotransporter 2 antibodyAnti-Sodium-Coupled Nucleoside Transporter 2 antibodyAnti-Sodium/Purine Nucleoside Co-Transporter antibodyAnti-Spnt antibodyAnti-Solute Carrier Family 28 Member 2 antibodyAnti-SLC28A2 antibodyAnti-CNT2 antibody |
Information sourced from Uniprot.org
