| Tissue Specificity | Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer. |
| Post Translational Modifications | The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration. |
| Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. |
| Protein Name | Sodium/Potassium/Calcium Exchanger 1Na(+/K(+/Ca(2+-Exchange Protein 1Retinal Rod Na-Ca+K ExchangerSolute Carrier Family 24 Member 1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-425561Reactome: R-HSA-5619077 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Potassium/Calcium Exchanger 1 antibodyAnti-Na(+/K(+/Ca(2+-Exchange Protein 1 antibodyAnti-Retinal Rod Na-Ca+K Exchanger antibodyAnti-Solute Carrier Family 24 Member 1 antibodyAnti-SLC24A1 antibodyAnti-KIAA0702 antibodyAnti-NCKX1 antibody |
Information sourced from Uniprot.org
