| Tissue Specificity | Specifically expressed in liver (also at protein level). |
| Function | Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS). Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised. It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate). May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes. |
| Protein Name | Organic Anion Transporter 7Oat7Organic Anion/Short-Chain Fatty Acid ExchangerSolute Carrier Family 22 Member 9 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinEnriched At The Sinusoidal Part Of The Plasma Membrane |
| Alternative Antibody Names | Anti-Organic Anion Transporter 7 antibodyAnti-Oat7 antibodyAnti-Organic Anion/Short-Chain Fatty Acid Exchanger antibodyAnti-Solute Carrier Family 22 Member 9 antibodyAnti-SLC22A9 antibodyAnti-hOAT4 antibodyAnti-OAT7 antibodyAnti-UST3 antibody |
Information sourced from Uniprot.org
