| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC22A15 |
| Gene ID: | 55356 |
| Uniprot ID: | S22AF_HUMAN |
| Immunogen Region: | 443-547 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 443-547 of human SLC22A15 (NP_060890.2). |
| Immunogen Sequence: | RVGGIIAPFIPSLKYVQWSL PFIVFGATGLTSGLLSLLLP ETLNSPLLETFSDLQVYSYR RLGEEALSLQALDPQQCVDK ESSLGSESEEEEEFYDADEE TQMIK |
| Tissue Specificity | Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines. |
| Post Translational Modifications | N-glycosylated. |
| Function | Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations. Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation. Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transport agmatine. The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated (Probable). |
| Protein Name | Solute Carrier Family 22 Member 15 Fly-Like Putative Transporter 1 Flipt 1 |
| Database Links | Reactome: R-HSA-549127 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 15 antibody Anti-Fly-Like Putative Transporter 1 antibody Anti-Flipt 1 antibody Anti-SLC22A15 antibody Anti-FLIPT1 antibody Anti-UNQ9429 antibody Anti-PRO34686 antibody |
Information sourced from Uniprot.org