| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC22A15 (443-547) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC22A15 |
| Gene ID: |
55356 |
| Uniprot ID: |
S22AF_HUMAN |
| Immunogen Region: |
443-547 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 443-547 of human SLC22A15 (NP_060890.2). |
| Immunogen Sequence: |
RVGGIIAPFIPSLKYVQWSL PFIVFGATGLTSGLLSLLLP ETLNSPLLETFSDLQVYSYR RLGEEALSLQALDPQQCVDK ESSLGSESEEEEEFYDADEE TQMIK |
| Tissue Specificity | Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines. |
| Post Translational Modifications | N-glycosylated. |
| Function | Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations. Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation. Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transports agmatine. The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated (Probable). |
| Protein Name | Solute Carrier Family 22 Member 15Fly-Like Putative Transporter 1Flipt 1 |
| Database Links | Reactome: R-HSA-549127 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 15 antibodyAnti-Fly-Like Putative Transporter 1 antibodyAnti-Flipt 1 antibodyAnti-SLC22A15 antibodyAnti-FLIPT1 antibodyAnti-UNQ9429 antibodyAnti-PRO34686 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
