| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SHC3 |
| Gene ID: |
53358 |
| Uniprot ID: |
SHC3_HUMAN |
| Immunogen Region: |
310-450 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 310-450 of human SHC3 (NP_058544.3). |
| Immunogen Sequence: |
QCPTKIPALHDRMQSLDEPW TEEEGDGSDHPYYNSIPSKM PPPGGFLDTRLKPRPHAPDT AQFAGKEQTYYQGRHLGDTF GEDWQQTPLRQGSSDIYSTP EGKLHVAPTGEAPTYVNTQQ IPPQAWPAAVSSAESSPRKD L |
| Tissue Specificity | Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. |
| Protein Name | Shc-Transforming Protein 3Neuronal ShcN-ShcProtein RaiShc-Transforming Protein CSrc Homology 2 Domain-Containing-Transforming Protein C3Sh2 Domain Protein C3 |
| Database Links | Reactome: R-HSA-167044Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Alternative Antibody Names | Anti-Shc-Transforming Protein 3 antibodyAnti-Neuronal Shc antibodyAnti-N-Shc antibodyAnti-Protein Rai antibodyAnti-Shc-Transforming Protein C antibodyAnti-Src Homology 2 Domain-Containing-Transforming Protein C3 antibodyAnti-Sh2 Domain Protein C3 antibodyAnti-SHC3 antibodyAnti-NSHC antibodyAnti-SHCC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
