| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SH3 domain-binding protein 5 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SH3BP5 |
| Gene ID: | 9467 |
| Uniprot ID: | 3BP5_HUMAN |
| Specificity: | This antibody detects endogenous levels of SH3BP5 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human SH3BP5 |
| Function | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. |
| Protein Name | Sh3 Domain-Binding Protein 5Sh3bp-5Sh3 Domain-Binding Protein That Preferentially Associates With Btk |
| Cellular Localisation | Cytoplasmic Vesicle MembranePeripheral Membrane ProteinMitochondrionColocalizes With Rab11a On Cytoplasmic Vesicle Membranes |
| Alternative Antibody Names | Anti-Sh3 Domain-Binding Protein 5 antibodyAnti-Sh3bp-5 antibodyAnti-Sh3 Domain-Binding Protein That Preferentially Associates With Btk antibodyAnti-SH3BP5 antibodyAnti-SAB antibody |
Information sourced from Uniprot.org