| Tissue Specificity | Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). |
| Post Translational Modifications | Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2. |
| Function | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. |
| Protein Name | Sh3 Domain-Binding Protein 4Eh-Binding Protein 10Transferrin Receptor-Trafficking Protein |
| Database Links | Reactome: R-HSA-9639288 |
| Cellular Localisation | MembraneClathrin-Coated PitCytoplasmic VesicleClathrin-Coated VesicleNucleusSpecifically Associated With Transferrin Receptor-Containing Clathrin-Coated Pits And Clathrin-Coated VesiclesMay Also Localize To The Nucleus |
| Alternative Antibody Names | Anti-Sh3 Domain-Binding Protein 4 antibodyAnti-Eh-Binding Protein 10 antibodyAnti-Transferrin Receptor-Trafficking Protein antibodyAnti-SH3BP4 antibodyAnti-BOG25 antibodyAnti-EHB10 antibodyAnti-TTP antibody |
Information sourced from Uniprot.org
