| Function | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation.downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling. In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse. Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation. |
| Protein Name | Sh2 Domain-Containing Protein 1bEws/Fli1-Activated Transcript 2Eat-2 |
| Database Links | Reactome: R-HSA-198933 |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 1b antibodyAnti-Ews/Fli1-Activated Transcript 2 antibodyAnti-Eat-2 antibodyAnti-SH2D1B antibodyAnti-EAT2 antibody |
Information sourced from Uniprot.org
