| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SFTPD (50-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SFTPD |
| Gene ID: |
6441 |
| Uniprot ID: |
SFTPD_HUMAN |
| Immunogen Region: |
50-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-220 of human Surfactant protein D/SP-D (NP_003010.4). |
| Immunogen Sequence: |
RDGRDGREGPRGEKGDPGLP GAAGQAGMPGQAGPVGPKGD NGSVGEPGPKGDTGPSGPPG PPGVPGPAGREGPLGKQGNI GPQGKPGPKGEAGPKGEVGA PGMQGSAGARGLAGPKGERG VPGERGVPGNTGAAGSAGAM GPQGSPGARGPPGLKGDKGI PGDKGAKGESG |
| Tissue Specificity | Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). |
| Post Translational Modifications | The N-terminus is blocked. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages. |
| Function | Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. |
| Protein Name | Pulmonary Surfactant-Associated Protein DPsp-DSp-DCollectin-7Lung Surfactant Protein D |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-168179Reactome: R-HSA-198933Reactome: R-HSA-391160Reactome: R-HSA-5683826Reactome: R-HSA-5686938Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-9692916Reactome: R-HSA-9705671 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSurface Film |
| Alternative Antibody Names | Anti-Pulmonary Surfactant-Associated Protein D antibodyAnti-Psp-D antibodyAnti-Sp-D antibodyAnti-Collectin-7 antibodyAnti-Lung Surfactant Protein D antibodyAnti-SFTPD antibodyAnti-COLEC7 antibodyAnti-PSPD antibodyAnti-SFTP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
