| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Histone-Lysine N-Methyltransferase Setd1b (150-250) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SETD1BUniprot ID=SET1B_HUMAN" |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SETD1B (NP_001340274.1). |
| Immunogen Sequence: |
VFATVRGAKDAVQHLHSTSV MGNIIHVELDTKGETRMRFY ELLVTGRYTPQTLPVGELDA VSPIVNETLQLSDALKRLKD GGLSAGCGSGSSSVTPNSGG T |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd1bLysine N-Methyltransferase 2gSet Domain-Containing Protein 1bHset1b |
| Cellular Localisation | Nucleus SpeckleChromosomeLocalizes To A Largely Non-Overlapping Set Of Euchromatic Nuclear Speckles With Setd1aSuggesting That Setd1a And Set1b Each Bind To A Unique Set Of Target Genes |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd1b antibodyAnti-Lysine N-Methyltransferase 2g antibodyAnti-Set Domain-Containing Protein 1b antibodyAnti-Hset1b antibodyAnti-SETD1B antibodyAnti-KIAA1076 antibodyAnti-KMT2G antibodyAnti-SET1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
