| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPINE1 |
| Gene ID: | 5054 |
| Uniprot ID: | PAI1_HUMAN |
| Immunogen Region: | 24-158 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-158 of human PAI-1/Serpin E1 (NP_000593.1). |
| Immunogen Sequence: | VHHPPSYVAHLASDFGVRVF QQVAQASKDRNVVFSPYGVA SVLAMLQLTTGGETQQQIQA AMGFKIDDKGMAPALRHLYK ELMGPWNKDEISTTDAIFVQ RDLKLVQGFMPHFFRLFRST VKQVDFSEVERARFI |
| Tissue Specificity | Expressed in endothelial cells. Found in plasma, platelets, and hepatoma and fibrosarcoma cells. |
| Post Translational Modifications | Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. |
| Function | Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. |
| Protein Name | Plasminogen Activator Inhibitor 1 Pai Pai-1 Endothelial Plasminogen Activator Inhibitor Serpin E1 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-1368108 Reactome: R-HSA-2173796 Reactome: R-HSA-3000178 Reactome: R-HSA-75205 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasminogen Activator Inhibitor 1 antibody Anti-Pai antibody Anti-Pai-1 antibody Anti-Endothelial Plasminogen Activator Inhibitor antibody Anti-Serpin E1 antibody Anti-SERPINE1 antibody Anti-PAI1 antibody Anti-PLANH1 antibody |
Information sourced from Uniprot.org