| Tissue Specificity | Ubiquitous. |
| Function | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Isoform 6 acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. |
| Protein Name | N-Terminal Kinase-Like ProteinCoated Vesicle-Associated Kinase Of 90 KdaScy1-Like Protein 1Telomerase Regulation-Associated ProteinTelomerase Transcriptional Element-Interacting FactorTeratoma-Associated Tyrosine Kinase |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkLocalized To The Endoplasmic Reticulum-Golgi Intermediate And Cis-Golgi In An Arf1-Independent MannerIsoform 1: CytoplasmCytoplasmic Throughout The Cell CycleIsoform 2: CytoplasmIsoform 3: CytoplasmCytoplasmic During Interphase And Centrosomal During MitosisIt Localizes To The Centrosomes In A Microtubule-Independent MannerIsoform 6: Nucleus |
| Alternative Antibody Names | Anti-N-Terminal Kinase-Like Protein antibodyAnti-Coated Vesicle-Associated Kinase Of 90 Kda antibodyAnti-Scy1-Like Protein 1 antibodyAnti-Telomerase Regulation-Associated Protein antibodyAnti-Telomerase Transcriptional Element-Interacting Factor antibodyAnti-Teratoma-Associated Tyrosine Kinase antibodyAnti-SCYL1 antibodyAnti-CVAK90 antibodyAnti-GKLP antibodyAnti-NTKL antibodyAnti-TAPK antibodyAnti-TEIF antibodyAnti-TRAP antibodyAnti-HT019 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and SCYL1 knockout (KO) 293T cells, using [KO Validated] SCYL1 Rabbit polyclonal antibody (STJ11100789) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/89725/358206/STJ11100789_1__78321.1713122528.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SCYL1 knockout (KO) 293T cells, using [KO Validated] SCYL1 Rabbit polyclonal antibody (STJ11100789) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
![Western blot analysis of lysates from wild type (WT) and SCYL1 knockout (KO) 293T cells, using [KO Validated] SCYL1 Rabbit polyclonal antibody (STJ11100789) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/89725/358206/STJ11100789_1__78321.1713122528.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SCYL1 knockout (KO) 293T cells, using [KO Validated] SCYL1 Rabbit polyclonal antibody (STJ11100789) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
