| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCNN1B |
| Gene ID: | 6338 |
| Uniprot ID: | SCNNB_HUMAN |
| Immunogen Region: | 406-640 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 406-640 of human SCNN1B (NP_000327.2). |
| Immunogen Sequence: | YPLPRGEKYCNNRDFPDWAH CYSDLQMSVAQRETCIGMCK ESCNDTQYKMTISMADWPSE ASEDWIFHVLSQERDQSTNI TLSRKGIVKLNIYFQEFNYR TIEESAANNIVWLLSNLGGQ FGFWMGGSVLCLIEFGEIII DFVWITIIKLVALAKSLRQR RAQASYAGPPPTVAELVEAH TNFGFQPDTAPRSPNTGPYP SEQALPIPGTPPPNYDSLRL QPLDVIESDSEGDAI |
| Tissue Specificity | Detected in placenta, lung and kidney. Expressed in kidney (at protein level). |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. N-glycosylated. N-glycosylation is required for interaction with BPIFA1. |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Protein Name | Amiloride-Sensitive Sodium Channel Subunit Beta Beta-Nach Epithelial Na(+ Channel Subunit Beta Beta-Enac Enacb Nonvoltage-Gated Sodium Channel 1 Subunit Beta Scneb |
| Database Links | Reactome: R-HSA-2672351 Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Membrane Apical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Amiloride-Sensitive Sodium Channel Subunit Beta antibody Anti-Beta-Nach antibody Anti-Epithelial Na(+ Channel Subunit Beta antibody Anti-Beta-Enac antibody Anti-Enacb antibody Anti-Nonvoltage-Gated Sodium Channel 1 Subunit Beta antibody Anti-Scneb antibody Anti-SCNN1B antibody |
Information sourced from Uniprot.org