| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SBF1 |
| Gene ID: |
6305 |
| Uniprot ID: |
MTMR5_HUMAN |
| Immunogen Region: |
1630-1770 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1770 of human SBF1 (NP_002963.2). |
| Immunogen Sequence: |
PPYDWELAQGPPEPPEEERS DGGAPQSRRRVVWPCYDSCP RAQPDAISRLLEELQRLETE LGQPAERWKDTWDRVKAAQR LEGRPDGRGTPSSLLVSTAP HHRRSLGVYLQEGPVGSTLS LSLDSDQSSGSTTSGSRQAA R |
| Tissue Specificity | Expressed in neurons within the frontal cortex, in neurons of the deep cerebellar nuclei, stellate and basket cells of the molecular layer, and Golgi cells of the granular layer (at protein level). |
| Function | Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Acts as a suppressor of autophagy in neurons. Together with its binding partner, the phosphatase MTMR2, plays a role in dephosphorylation of phosphoinositides critical for autophagy initiation and autophagosome maturation. Plays a role in positively regulating late-stage radial sorting of large caliber axons, a process leading to myelination by Schwann cells, possibly via regulating endosomal trafficking. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. |
| Protein Name | Myotubularin-Related Protein 5Inactive Phosphatidylinositol 3-Phosphatase 5Set-Binding Factor 1Sbf1 |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionNeuron ProjectionLocalized In Neuronal Somata And Processes With Punctate/Vesicular Morphology |
| Alternative Antibody Names | Anti-Myotubularin-Related Protein 5 antibodyAnti-Inactive Phosphatidylinositol 3-Phosphatase 5 antibodyAnti-Set-Binding Factor 1 antibodyAnti-Sbf1 antibodyAnti-SBF1 antibodyAnti-MTMR5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
