| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SAP18 |
| Gene ID: | 10284 |
| Uniprot ID: | SAP18_HUMAN |
| Immunogen Region: | 21-172 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_005861.2). |
| Immunogen Sequence: | AVESRVTQEEIKKEPEKPID REKTCPLLLRVFTTNNGRHH RMDEFSRGNVPSSELQIYTW MDATLKELTSLVKEVYPEAR KKGTHFNFAIVFTDVKRPGY RVKEIGSTMSGRKGTDDSMT LQSQKFQIGDYLDIAITPPN RAPPPSGRMRPY |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes).specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S).the activity is different from the established EJC assembly and function. |
| Protein Name | Histone Deacetylase Complex Subunit Sap18 18 Kda Sin3-Associated Polypeptide 2hor0202 Cell Growth-Inhibiting Gene 38 Protein Sin3-Associated Polypeptide P18 |
| Database Links | Reactome: R-HSA-3214815 Reactome: R-HSA-427413 Reactome: R-HSA-72163 Reactome: R-HSA-9679191 |
| Cellular Localisation | Nucleus Cytoplasm Nucleus Speckle Shuttles Between The Nucleus And The Cytoplasm Colocalizes With Acin1 And Srsf2 In Nuclear Speckles |
| Alternative Antibody Names | Anti-Histone Deacetylase Complex Subunit Sap18 antibody Anti-18 Kda Sin3-Associated Polypeptide antibody Anti-2hor0202 antibody Anti-Cell Growth-Inhibiting Gene 38 Protein antibody Anti-Sin3-Associated Polypeptide P18 antibody Anti-SAP18 antibody Anti-GIG38 antibody |
Information sourced from Uniprot.org