| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule. |
| Function | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. |
| Protein Name | Protein Salvador Homolog 145 Kda Ww Domain ProteinHww45 |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein Salvador Homolog 1 antibodyAnti-45 Kda Ww Domain Protein antibodyAnti-Hww45 antibodyAnti-SAV1 antibodyAnti-WW45 antibody |
Information sourced from Uniprot.org
