| Host: | Goat |
| Applications: | Pep-ELISA/WB/IF |
| Reactivity: | Human/Mouse/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SAE2/UBA2 (N-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: This product has been successfully used in Western blot on Mouse: Kanemaru A, Saitoh H., Biosci Biotechnol Biochem. 2013;77 (7) :1575-8. PMID: 23832333.IF: Strong expression of th |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | UBA2 |
| Gene ID: | 10054 |
| Uniprot ID: | SAE2_HUMAN |
| Immunogen Region: | N-Term |
| Accession Number: | NP_005490 |
| Immunogen Sequence: | ALSRGLPRELAEA |
| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
| Protein Name | Sumo-Activating Enzyme Subunit 2Anthracycline-Associated Resistance ArxUbiquitin-Like 1-Activating Enzyme E1bUbiquitin-Like Modifier-Activating Enzyme 2 |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The NucleusSumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention |
| Alternative Antibody Names | Anti-Sumo-Activating Enzyme Subunit 2 antibodyAnti-Anthracycline-Associated Resistance Arx antibodyAnti-Ubiquitin-Like 1-Activating Enzyme E1b antibodyAnti-Ubiquitin-Like Modifier-Activating Enzyme 2 antibodyAnti-UBA2 antibodyAnti-SAE2 antibodyAnti-UBLE1B antibodyAnti-HRIHFB2115 antibody |
Information sourced from Uniprot.org