| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | S100A1 |
| Gene ID: | 6271 |
| Uniprot ID: | S10A1_HUMAN |
| Immunogen Region: | 40 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 40 to the C-terminus of human S100/S100A1 (NP_006262.1). |
| Immunogen Sequence: | TELSGFLDAQKDVDAVDKVM KELDENGDGEVDFQEYVVLV AALTVACNNFFWENS |
| Tissue Specificity | Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. |
| Post Translational Modifications | Glutathionylated.glutathionylation increases affinity to calcium about 10-fold. |
| Function | Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. |
| Protein Name | Protein S100-A1 S-100 Protein Alpha Chain S-100 Protein Subunit Alpha S100 Calcium-Binding Protein A1 |
| Database Links | Reactome: R-HSA-1236974 Reactome: R-HSA-166058 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 |
| Cellular Localisation | Cytoplasm Sarcoplasmic Reticulum Mitochondrion |
| Alternative Antibody Names | Anti-Protein S100-A1 antibody Anti-S-100 Protein Alpha Chain antibody Anti-S-100 Protein Subunit Alpha antibody Anti-S100 Calcium-Binding Protein A1 antibody Anti-S100A1 antibody Anti-S100A antibody |
Information sourced from Uniprot.org