| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RUFY3 |
| Gene ID: | 22902 |
| Uniprot ID: | RUFY3_HUMAN |
| Immunogen Region: | 1-65 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human RUFY3 (NP_055776.1). |
| Immunogen Sequence: | MSALTPPTDMPTPTTDKITQ AAMETIYLCKFRVSMDGEWL CLRELDDISLTPDPEPTHED PNYLM |
| Tissue Specificity | Overexpressed in gastric cancer cells and tissues (at protein level). |
| Post Translational Modifications | Phosphorylated by PAK1. Isoform 1 is partially phosphorylated. |
| Function | Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. |
| Protein Name | Protein Rufy3 Run And Fyve Domain-Containing Protein 3 Rap2-Interacting Protein X Ripx Single Axon-Regulated Protein Singar |
| Cellular Localisation | Cytoplasm Endomembrane System Cell Projection Invadopodium Perikaryon Growth Cone Filopodium Lamellipodium Colocalizes With Pak1 F-Actin Myosins And Integrins In Invadopodia At The Cell Periphery Colocalized With Ras-Related Rab-5 Proteins In Cytoplasmic Vesicles Accumulates In Axon Growth Cones In A F-Actin-Dependent Manner Colocalized With Fscn1 And F-Actin At Filipodia And Lamellipodia Of Axonal Growth Cones Colocalized With Dbn1 And F-Actin At Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Protein Rufy3 antibody Anti-Run And Fyve Domain-Containing Protein 3 antibody Anti-Rap2-Interacting Protein X antibody Anti-Ripx antibody Anti-Single Axon-Regulated Protein antibody Anti-Singar antibody Anti-RUFY3 antibody Anti-KIAA0871 antibody |
Information sourced from Uniprot.org