| Tissue Specificity | Overexpressed in gastric cancer cells and tissues (at protein level). |
| Post Translational Modifications | Phosphorylated by PAK1. Isoform 1 is partially phosphorylated. |
| Function | Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. |
| Protein Name | Protein Rufy3Run And Fyve Domain-Containing Protein 3Rap2-Interacting Protein XRipxSingle Axon-Regulated ProteinSingar |
| Cellular Localisation | CytoplasmEndomembrane SystemCell ProjectionInvadopodiumPerikaryonGrowth ConeFilopodiumLamellipodiumColocalizes With Pak1F-ActinMyosins And Integrins In Invadopodia At The Cell PeripheryColocalized With Ras-Related Rab-5 Proteins In Cytoplasmic VesiclesAccumulates In Axon Growth Cones In A F-Actin-Dependent MannerColocalized With Fscn1 And F-Actin At Filipodia And Lamellipodia Of Axonal Growth ConesColocalized With Dbn1 And F-Actin At Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Protein Rufy3 antibodyAnti-Run And Fyve Domain-Containing Protein 3 antibodyAnti-Rap2-Interacting Protein X antibodyAnti-Ripx antibodyAnti-Single Axon-Regulated Protein antibodyAnti-Singar antibodyAnti-RUFY3 antibodyAnti-KIAA0871 antibody |
Information sourced from Uniprot.org
