| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RUFY3 (1-65) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RUFY3 |
| Gene ID: |
22902 |
| Uniprot ID: |
RUFY3_HUMAN |
| Immunogen Region: |
1-65 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human RUFY3 (NP_055776.1). |
| Immunogen Sequence: |
MSALTPPTDMPTPTTDKITQ AAMETIYLCKFRVSMDGEWL CLRELDDISLTPDPEPTHED PNYLM |
| Tissue Specificity | Overexpressed in gastric cancer cells and tissues (at protein level). |
| Post Translational Modifications | Phosphorylated by PAK1. Isoform 1 is partially phosphorylated. |
| Function | Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. |
| Protein Name | Protein Rufy3Run And Fyve Domain-Containing Protein 3Rap2-Interacting Protein XRipxSingle Axon-Regulated ProteinSingar |
| Cellular Localisation | CytoplasmEndomembrane SystemCell ProjectionInvadopodiumPerikaryonGrowth ConeFilopodiumLamellipodiumColocalizes With Pak1F-ActinMyosins And Integrins In Invadopodia At The Cell PeripheryColocalized With Ras-Related Rab-5 Proteins In Cytoplasmic VesiclesAccumulates In Axon Growth Cones In A F-Actin-Dependent MannerColocalized With Fscn1 And F-Actin At Filipodia And Lamellipodia Of Axonal Growth ConesColocalized With Dbn1 And F-Actin At Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Protein Rufy3 antibodyAnti-Run And Fyve Domain-Containing Protein 3 antibodyAnti-Rap2-Interacting Protein X antibodyAnti-Ripx antibodyAnti-Single Axon-Regulated Protein antibodyAnti-Singar antibodyAnti-RUFY3 antibodyAnti-KIAA0871 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
