| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RTCB |
| Gene ID: | 51493 |
| Uniprot ID: | RTCB_HUMAN |
| Immunogen Region: | 236-505 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 236-505 of human RTCB (NP_055121.1). |
| Immunogen Sequence: | EIFNEYAAKKMGIDHKGQVC VMIHSGSRGLGHQVATDALV AMEKAMKRDKIIVNDRQLAC ARIASPEGQDYLKGMAAAGN YAWVNRSSMTFLTRQAFAKV FNTTPDDLDLHVIYDVSHNI AKVEQHVVDGKERTLLVHRK GSTRAFPPHHPLIAVDYQLT GQPVLIGGTMGTCSYVLTGT EQGMTETFGTTCHGAGRALS RAKSRRNLDFQDVLDKLADM GIAIRVASPKLVMEEAPES |
| Function | Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. |
| Protein Name | Rna-Splicing Ligase Rtcb Homolog3'-Phosphate/5'-Hydroxy Nucleic Acid Ligase |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusCytoplasmEnters Into The Nucleus In Case Of Active Transcription While It Accumulates In Cytosol When Transcription Level Is Low |
| Alternative Antibody Names | Anti-Rna-Splicing Ligase Rtcb Homolog antibodyAnti-3'-Phosphate/5'-Hydroxy Nucleic Acid Ligase antibodyAnti-RTCB antibodyAnti-C22orf28 antibodyAnti-HSPC117 antibody |
Information sourced from Uniprot.org