| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RPUSD4 (1-377) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RPUSD4 |
| Gene ID: |
84881 |
| Uniprot ID: |
RUSD4_HUMAN |
| Immunogen Region: |
1-377 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human RPUSD4 (NP_116184.2). |
| Immunogen Sequence: |
MAAPRWSASGPWIRGNGQGC GSLFTLVSKPFCAAAAASTA INAQRLAEKLRAQKREQDTK KEPVSTNAVQRRVQEIVRFT RQLQRVHPNVLAKALTRGIL HQDKNLVVINKPYGLPVHGG PGVQLCITDVLPILAKMLHG HKAEPLHLCHRLDKETTGVM VLAWDKDMAHQVQELFRTRQ VVKKYWAITVHVPMPSAGVV DIPIVEKEAQGQQQHHKMTL SPSYRMDDGKMVKVRRSRN |
| Function | Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. |
| Protein Name | Pseudouridylate Synthase Rpusd4 - MitochondrialRna Pseudouridylate Synthase Domain-Containing Protein 4 |
| Cellular Localisation | Mitochondrion MatrixNucleusCytoplasmMainly Localizes To MitochondrionLocalizes To Mitochondrial Rna GranulesPlatforms For Post-Transcriptional Rna Modification And Ribosome AssemblyAlso Found In Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase Rpusd4 - Mitochondrial antibodyAnti-Rna Pseudouridylate Synthase Domain-Containing Protein 4 antibodyAnti-RPUSD4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
